After Kratos emerged from Aphrodite's Chamber, and had a brief conversation with him, Hephaestus convinced Kratos to retrieve the Omphalos Stone from the Pit of Tartarus, so that he could make him a Special Weapon. Kratos entered Tartarus, fought off a large pack of Olympus Sentries, as well as a Centaur General, and emerged at the Gates of Tisiphone. An image of the Pillar of the World was engraved onto the gates. Kratos solved the puzzle that was necessary to open the gates and continued his quest to the Omphalos Stone.
- Tisiphone was one of the three Furies in Greek mythology. She, along with her sisters, Alecto and Megaera, where tasked with torturing the evil souls condemned to the depths of Tartarus and are the main antagonists of God of War: Ascension. Tisiphone was also recognised as the furious and cruel guardian of the gates of Tartarus in the original mythology, revealing her relation to the gates.
- The Gates separated Tartarus in two parts, Tartarus and the Pit of Tartarus.