After the sons of the architect Pathos Verdes III died, he thought of using their skulls as keys to some doors of the Pandora's Temple that he was building. This decision caused a serious argument with his wife, whom he ended up killing in a fit of madness by sticking a knife into her chest.
When Kratos enters in the Architect's Tomb, the corpse of Pathos Verdes' wife can be seen on the table, sitting and stabbed with the knife.